Computed tomography scans carry a risk of teratogenesis and childhood hematologic malignancies but may be used judiciously with minimized radiation protocols (2–5 rads; conditional suggestion, very low stage of evidence). If the applicant has frequent exacerbations or any degree of exertional dyspnea, certification should be deferred. Individual trial quality was measured for enough sequence era, allocation concealment, how incomplete outcome information was addressed, and if free of selective reporting or other bias
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