Prophylactic therapies ought to be utilized using a “start-low and go slow” method. Curiously, Skd3 first seems in evolution alongside Hsp104 and Hsp78 in choanoflagellates, a gaggle of free-residing unicellular and colonial flagellate eukaryotes that are the closest extant protozoan relatives of animals. Sphingomyelin is degraded by the lysosomal phospholipase, sphingomyelinase (see below)
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