It is associated with gradual rolling eye rates as compared to those who sleep for 7–8 hr/night. Interactions of mixed (estrogen and progestogen) oral contraceptives can also apply to combined parenteral contraceptives. In addition, malformations that accompanied these of the limbs and ears have been pyloric stenosis, duodenal stenosis, duodenal atresia, cardiac defect, microphthalmos, anophthalmia, imperforate anus, and choanal atresia (62)
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