Clinical presentation the medical presentation of mitochondrial liver disease may be very extensive, ranging from prenatal manifestation as hydrops fetalis, acute neonatal liver failure (see Chapter 9), lactic acidosis, cholestasis, or continual liver disease. In 1880, Edoardo Perroncito first noted the correlation between hookworms and anemia amongst miners digging the St. Dose- limiting toxicity was hematologic and was reported with any dose but is expected to be extra extreme at higher doses medicine 230
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