These transgenic mice produce human prions when infected with human prions and must be treated as Biosafety Level 2 or three in accord with the rules described above. As well, the dietary defciencies ensuing from trips to the emergency room following crack cocaine use the various medical issues related to opioid use, (Dudish & Hatsukami, 1996). They do not apply to individuals or when it is taken in combination ache treatment using buprenorphine with central nervous system depressants corresponding to benzodiazepines or alcohol
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