The ?nding of increased osmotic fragility just isn't distinctive to hereditary sphero- transfusion-dependent sufferers. The vast majority of those stories have studied White populations in Europe, used limited definitions of the disorder, and/or used bias populations, similar to these seeking medical care. The test animal commonly used in skin sensitization checks is the guinea pig; animals are handled with the test compound in a suitable vehicle, with the automobile alone, or with a positive management such as 2, 4-dinitrochlorobenzene (a comparatively sturdy sensitizer) or cinnamaldehyde (a relatively weak sensitizer) in the same car
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