Patients who lost response had been switched from placebo to active therapy at 5 mg/kg, or the re-treatment dose was increased from 5 to 10 mg/kg. The conference rendered help from the Ministry of Health of Romania, who're motivated to carry forth the National Plan for Rare Diseases in the near future. Pure midzonal and periportal necrosis are uncommon; the latter could also be seen in eclampsia
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