With polyuria (usually massive volumes with osmolality < 200 mOsm/kg), polydipsia, and hypernatremia if the sufferers wouldn't have an intact thirst mechanism or don't drink water. Again, the characterization of the quantified results of methyl isocyanate as being acute toxicity implies that this quantification was derived from a short-term dosing experiment and that the response measured occurred inside a short while period following dosing. The establishment of centres of experience and healthcare pathways might be one of the first topics to be dealt with within the elaboration of a national plan for uncommon illnesses with a stepwise method for designation envisaged
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