Verrucous pores and skin lesions of the face and limbs, cobblestone-like papules of the gingiva and buccal mucosa, and multi ple facial trichilemmomas are leading ndings. Symptoms may be screened according to regional guidelines, or by using the next stepped method: Step 1: Initial questions might embrace: Over the last 2 weeks, how typically have you been bothered by the next problems?. Thalassemia is also an example of a polymorphism maintained by heterozygote benefit in areas where malaria is endemic
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