Adverse results embrace death, structural abnormalities, altered progress, and functional deficiencies. The rash is normally a nice erythema, commonly punctate, blanching on stress, often felt (like sandpaper) higher than seen and appearing most often on the neck, chest, folds of the axilla, elbow, groin and inside surfaces of the thighs. The direct stimulatory or inhibitory impact of P4 on steroidogenesis in Leydig cells has been demonstrated, though its mode of action remains obscure (El-Hefnawy et al symptoms schizophrenia
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