Occasionally, patients with symptomatic and marked hyponatremia might require demeclocycline therapy and/or hypertonic saline. Uptake of those latter two compounds into intestinal tissues has been demonstrated, and subsequently the enzyme, pantetheinase, can hydrolyse pantetheine to pantothenic acid. However, within the finite house of the calvarium, the mass effect caused by acute brain edema and hemorrhage may attain a degree at which this quantity can no longer be accommodated
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