It often occurred within the first few cycles of therapy and was not cumulative. Four sufferers (2%) had definite Cushing’s syndrome and 7 had subclinical hypercortisolism with unilateral adrenal adenomas demonstrating uptake on iodocholesterol scintigraphy and elevated late-night cortisol levels. This defect produces anterior herniation of the bladder, bladder neck, and urethra
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