Epidemiology: the worldwide incidence of retinitis pigmentosa is estimated at between one per 35000 and one per 70000 persons. Children with DownпїЅs syndrome invariably have severe mental retardation, which progressively declines with advancing age. Other issues include the widespread incidence of asymptomatic biochemical hypoglycaemia that is solely evident if blood glucose is measured regularly, and the failure to recognize or report many mild episodes, together with those during sleep
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